This book is a collection of high-quality research papers presented at the International Conference on Smart and Intelligent Systems (SIS 2021), which will be held in Velagapudi Ramakrishna Siddhartha Engineering College (VRSEC), Andhra Pradesh, India, during February 25–26, 2021, in virtual mode. It highlights how recent informatics intelligent systems have successfully been used to develop innovative smart techniques and infrastructure in the field of modern engineering and technology.