The purpose of this book is to educate readers regarding the efficacy of cognitive rehabilitation across a variety of neurological conditions, with specific emphasis on rehabilitation-related change detectable via neuroimaging. For ease of reference, this information is divided into separate chapters by neurological condition, since the nature of cognitive impairment and mechanism of rehabilitation may differ across populations. Also included are discussions of the use of neuroimaging in cognitive rehabilitation trials, rigorous design of cognitive rehabilitation trials to have greater scientific impact (e.g., obtaining Class I evidence), and future directions for the field.